second line of defense

IMMUNOLOGY: SECOND LINE OF DEFENSE

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second line of defense

Reinforcement, the use of machinery and the opt for the use of sophisticated weapons is perhaps every General’s best strategy for putting an end to a lingering war. The second line of defense in immunlogy help in the complete elimination of intruding microorganisms in the body. Second line of defense is also known as the adaptive immune system.

We hereby urge our readers to read our previous articles: Introduction to immunology and immunology: first line of defense for better understanding before continuing in this article.

Below are the cells that put the final blow to invading microorganisms in the body.

  1. Neutrophils
  2. Monocytes
  3. Lymphocytes

The neutrophils and monocytes

The neutrophils and monocytes which have phagocytic abilities are usually the first set of white blood cells to recognize invading bacteria. Often times, they kill the ingested microorganisms through the production of hyper-reactive types of oxygen (peroxides, superoxides) as well as the secretion of enzymes that altogether kill invading bacteria. However, in most cases, they present the bacteria antigen on their surface in form of (Major Histocompatibility complex I or II) and release cytokines (interleukins), a chemical substance that causes the T- cells to come to the cells and do the final blow on the bacteria antigens.

cluster of differentiation

The lymphocytes

The lymphocytes such as the B-cells, the T-cells and the natural killer cells also play a vital role in the body’s second line of defense.

Immunity conferred on the body by the B- cells cells are also referred to as humoral immunity while immunity conferred on the body by the T-cells are referred to as cell-mediated immunity.

Types of T-cells

  • Helper T-cells (CD4+ T-cells)
  • Cytotoxic T-cells (CD8+ T-cells)
  • Memory T- cells

CD (means Cluster of differentiation). The major difference between the helper T-cells and the Cytotoxic T-cells is that; helper T-cells only recognize MHC II presented by antigen presenting cells while the Cytotoxic T- cells recognize only the MHC I presented on the cell surface of antigen presenting cells.

B- cells

The B-cell also have phagocytic abilities, they engulf bacteria, release cytokines which attract receptors on T-cells, thus activating the B-cells to differentiate into both plasma cells that produce antibodies and memory B-cells that store information about the intruding microorganisms, and elevate attack against such microorganisms upon subsequent exposure of individual to such microorganisms while the T-cells likewise differentiate into memory T-cells.

Memory B-cells and memory T- cells store the information against the microorganisms and prevent invasion by such a microorganism attack in the future. Once the body comes across such microorganism in future it produces an elevated attack on the microorganisms, thus, leading to quick elimination of such bacteria. This explains the reason why an individual that survives measles and chicken pox disease are usually immune to the subsequent outbreak of such disease.

Natural Killer Cells

The Natural killer cells are another type of lymphocytes that targets and destroys cells infected with viruses and abnormally cancer growing cells.

Cite this article as: Fagbohun, S.O., "IMMUNOLOGY: SECOND LINE OF DEFENSE," in ATG Ventures, 09/02/2019, https://atgventure.com/immunology-second-line-of-defense/.

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